報(bào)告題目：Opportunities for Porous Silicon in Nanomedicine
報(bào)告人：Nicolas Voelcker教授
講座時(shí)間：2018年11月13日上午9：00
講座地點(diǎn)：友誼校區(qū)老圖書(shū)館401
邀請(qǐng)人：李林 教授
承辦單位：柔性電子研究院
聯(lián)系人：王添
聯(lián)系電話(huà)：18269103286
報(bào)告簡(jiǎn)介：
This talk will explore the application of nanostructured silicon including porous silicon and silicon nanowires in drug and gene delivery, optical and electrochemical biosensors and in regenerative medicine. These elemental silicon-based materials have high surface area of up to several hundreds of square meters per gram, facilitating loading of considerable amounts of bioactives. Second, pore size can be tailored over a wide range, spanning from the nano- to the microscale. Being able to 'dial in' a certain pore size allows for facile optimisation of topographical cues for attachment, guidance, proliferation and differentiation of target cells. At the same time, the rate of diffusive release of drugs can be tuned by adjusting the pore size. Third, the materials are biocompatible and biodegradable, with the nanostructured elemental silicon undergoing oxidative hydrolysis in aqueous medium at a rate that is easily tunable by means of the surface chemistry from hours to months. A diverse range of surface chemistries is available for this material, some of which are amenable to surface patterning, formation of surface-bound gradients and formation of silicon-polymer hybrid materials. Finally, thin films, membranes and particles of porous silicon display interferometric reflectance and photonic effects, which are responsive to binding of target biomolecules. This talk will first introduce nanostructured silicon material properties and fabrication and characterisation aspects, including describing strategies for nano- and microscale patterning and gradient formation. This will be followed by an overview of the work using porous silicon nanostructured films as optical and electrochemical transducers. Drug delivery applications for targeted cancer therapy, immunotherapy and the therapy of ocular diseases will be highlighted, and the use of nanostructured silicon in chronic wound diagnostics and theranostics will be discussed. Finally, the talk will provide an example of the use of porous carrier material for ocular cell therapy.
報(bào)告人簡(jiǎn)介：
Nicolas Voelcker教授于1999年獲得博士學(xué)位（RWTH Aachen），并在Scrippts Research Institute從事博士后工作3年，師從M.R. Ghadiri教授。2001年Nico加入Flinders University，并在2008年提拔為教授以及理學(xué)院副院長(zhǎng)。2012年Nico加入南澳大學(xué)（University of South Australia），并于同年成為Mawson Institute院長(zhǎng)。2017年Nico加入莫納什（Monash）大學(xué)藥學(xué)院（藥劑藥理學(xué)世界排名第二），并與同年成為Melbourne Centre for Nanofabrication (墨爾本納米中心，MCN)院長(zhǎng)以及澳大利亞聯(lián)邦科學(xué)與工業(yè)研究組織(CSIRO)科研領(lǐng)頭人。他同時(shí)還擔(dān)任莫納什大學(xué)工程與材料學(xué)院教授，以及Leibniz Institute for New Materials（德國(guó)）客座教授，University Rovira I Virgili（西班牙）客座教授。他還是澳大利亞皇家化學(xué)學(xué)會(huì)，和英國(guó)皇家化學(xué)學(xué)會(huì)理事。
Nico在生物納米材料和生物表面材料上作出了許多貢獻(xiàn)。在多孔硅納米材料（Porous Silicon Nanoparticles, pSiNPs）的生物應(yīng)用上Nico作出了開(kāi)創(chuàng)性研究（超過(guò)100篇高質(zhì)量文章），并享有極高的國(guó)際聲譽(yù)（多孔硅材料世界前五）。他還設(shè)計(jì)了多孔硅傳感器，利用材料特質(zhì)從而提高了信號(hào)強(qiáng)度。Nico還在納米針以及納米線(xiàn)上發(fā)表了多篇高質(zhì)量文章。迄今為止Nico共發(fā)表了350篇學(xué)術(shù)論文，10本書(shū)以及25項(xiàng)專(zhuān)利，總引數(shù)超過(guò)7500次，年引用次數(shù)超過(guò)1100次/年，h-index 49，其中包括國(guó)際學(xué)術(shù)期刊Nature Communication, Nature Nanotechnology, Advanced Material, Advanced Functional Material以及Biometerial等。Nico已經(jīng)獲得了十余項(xiàng)獎(jiǎng)項(xiàng)，包括南澳年度科學(xué)家（2015）。
